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Antidepressants are used to alter the concentration of neurotransmitters in the brain that is responsible for the depressed affect (feelings in response to the environment, whether positive and pleasant or negative and unpleasant). But your doctor may start you on a lower dose, then increase it gradually to a maximum dose of 200mg a day. Find out how sertraline treats depression and other mental health conditions, and how to take it. Taking sertraline with other medicines and herbal supplements.

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